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Iohexol and iothalamate were studied in 2 strengths and compared with results from a previous trial of Iopamidol and 4 ionic agents. Scoring was consistent from trial to trial. No worthwhile increase in density was achieved at high doses using nonionics and pyelographic distention was less than for ionic media. The timing of the nephrogram was the same for ionics and nonionics. There is no need to adopt a different film sequence for nonionic media. Urticarial reactions were identical for all 4 media studied in this trial. Nonionic media perform as well as other media; at lower doses they are much better than meglumine salts of ionic media.

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