originals (any pharmaceutical released before 01/08/1987, per 2007 decree). The product reference price was assumed to be 100 for all groups. The effect of amended regulations was estimated for all five product groups by applying the changed discount rates to the reference price throughout the years 2004 to 2011. RESULTS: The reference price in 2004 was considerably different than in 2012. The price of original products without generics decreased from 100 to 59. The price of generics, and original products with generics decreased to 47.5. The 20-year-old original and generic products were affected the least, as the price of the 20-year-old original products decreased to 69.1 and of generics to 71.3. The different effects of regulations on each product group indicate that companies are heterogeneously affected depending on inventory. CONCLUSIONS: Drug groups were not uniformly affected by the regulations. With less overhead and expenses (e.g., clinical trials, marketing, promotions), generic drug manufactures are more easily adaptable to new regulations and market conditions. This may cause a shift to extensive production of generic medications in the Turkish pharmaceutical industry and decrease research and development investments. OBJECTIVES:To evaluate Public Perception towards Medicine Quality and Prices in Afghanistan. METHODS: A cross-sectional descriptive survey involving 1282 population in six zones of Afghanistan was undertaken. RESULTS: The study findings revealed that a total of (50.2%) of respondents agreed that imported medicines and (41.4%) said that locally manufactured medicines have good quality. High proportions (61.4%) of Afghan doctors are prescribing quality medicines, and also medicines given by public hospitals in Afghanistan are of high quality (54.9%). (38.4%) agreed that the afghan drug regulatory authority controls quality of medicine. Interestingly, (96.3%) respondents were agreed, that Afghan government should adopt health policies to control the medicine prices and expenditure. (89.6%) respondents agree that higher medicine costs negatively impacts patient outcomes. Half of the respondents (44.5%) say that in Afghanistan doctors have poor understandings on medicine prices. (68.7%) of respondents agreed that the price regulation system should be implemented from manufacturer to patients. When respondents asked, (94%) agreed that all medicine need to be disclosed on the dispensed medicine label. A round, (19.9%) of respondents agreed that medicine prices in Afghanistan are affordable to everyone. (93.1%) of the respondents said, prescription drug prices need to be regulated by the government. When respondents asked (68.2%) agreed that medicine prices are high in private hospitals. CONCLUSIONS: The first national survey on medicine quality and pricing, suggests that, the government should take firm steps to control the quality and disparate medicine prices, to ensure accessibility, availability and affordability of medicine to all. The drug regulatory authority has less control to regula...