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SYNOPSIS Serum a2-macroglobulin levels were measured in normal subjects and in patients with various diseases by an immunochemical method.The values for normal men were 284 mg./100 ml. (±89 6 mg./100 ml.) and for normal women 350 mg./100 ml. (±94 5 mg./100 ml.).Men with rheumatoid arthritis had normal levels, but the levels in women were depressed. There was no relationship to the concentrations of the acute phase reactive proteins, haptoglobin, and C-reactive protein.In chronic liver disease, the levels in men were significantly higher than normal and were slightly higher than normal in women.

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