Background and Aims Acute kidney injury is a global health problem. This study aims to determine the risk factors for poor outcome and to describe the clinical profile, etiology & outcomes of patients with Acute Kidney Injury (AKI) admitted to the Critical Care Unit from a tertiary care centre in South India. Method It was a prospective cohort study conducted in a tertiary care hospital in South India from December 2016 to Novemeber 2019. All patients in the ICU were screened for enrolment in AKI using RIFLE criteria with creatinine, GFR and urine output daily for a period of seven days. Results A total of 152 patients were taken for final analysis after exclusions. The mean age of the subjects was 44.15 years. Majority of the study subjects (55.9%) belonged to 26 – 50 years of age. Majority of the study subjects were females (51.3%) and the rest were males. Sepsis was found to be present in 52% (79) of the study subjects followed by Gastrointestinal loss 36.2% (55), crush injury 9.03% (15), snake bite 3.3% (5), poisoning 4.6% (7) and acute liver failure 1.3% (2). It was found that 62.5% (95) of the study subject’s AKI had resolved after appropriate management. Among the rest of the study subjects,27.6% required haemodialysis for recovery, 3.3% had persistence of AKI, 3.9% progressed to CKD and 2.6% died. The latter three categories were considered as poor outcomes of AKI. In our study, 29.8%people who had systemic hypertension and 28.2%people who had diabetes mellitus had poor outcome. It was found that in our study, sepsis and GI loss both contributes to poor outcome of AKI in univariate regression analysis whereas Gastrointestinal loss alone contributes to poor outcome of AKI with multivariate regression analysis. Conclusion In conclusion, even though sepsis is the commonest cause of AKI, Gastrointestinal loss independently contributes to poor outcome of AKI. Majority of the people recovered from AKI spontaneously with conservative management. Few people required dialysis for recovery of AKI & very few people progressed to CKD.

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