Innovation has been made in the caisson foundation to support a very large structure resting over a soft soil stratum known as the root-caisson foundation. This technique was executed in China-Yangtze River Bridge. The root caisson foundation was first implemented in the Yangtze River bridge and discovered that the root improves soil structure interaction and increases vertical bearing capacity by 100%. In the present research, a numerical study of root-caisson foundation under combined vertical and horizontal loading was performed using ABAQUS software. Analysis was performed by varying the parameters of root caisson such as the inclination of roots (30°, 45°, 60°, and 90°) spacing(S) between the root floors with respect to diameter (D) of the caisson as (0.5°D, 0.6°D, and 0.75°D) with different loading conditions and results were compared with normal traditional caisson with the same length (L) to diameter (D) ratio. From the test results, the load-settlement behavior of caisson is nonlinear for individual vertical, and lateral load tests and also the same for the combined loading conditions. It is found that the root-caisson has a higher load bearing capacity as compared to that of the traditional caisson. Moreover, in combined loading, the load bearing capacity increases considerably, compared with the ultimate vertical and lateral load capacity.