The extent, timing, and magnitude of soil moisture in wetlands (the hydropattern) is a primary physical control on biogeochemical processes in desert environments. However, determining playa hydropatterns is challenged by the remoteness of desert basin sites and by the difficulty in determining soil moisture from remotely sensed data at fine spatial and temporal scales (hundreds of meters to kilometers, and hours to days). Therefore, we developed a new, reflectance-based soil moisture index (continuum-removed water index, or CRWI) that can be determined via hyperspectral imaging from drone-borne platforms. We compared its efficacy at remotely determining soil moisture content to existing hyperspectral and multispectral soil moisture indices. CRWI varies linearly with in situ soil moisture content (R2 = 0.89, p < 0.001) and is comparatively insensitive to soil clay content (R2 = 0.4, p = 0.01), soil salinity (R2 = 0.82, p < 0.001), and soil grain size distribution (R2 = 0.67, p < 0.001). CRWI is negatively correlated with clay content, indicating it is not sensitive to hydrated mineral absorption features. CRWI has stronger correlation with surface soil moisture than other hyperspectral and multispectral indices (R2 = 0.69, p < 0.001 for WISOIL at this site). Drone-borne reflectance measurements allow monitoring of soil moisture conditions at the Alvord Desert playa test site over hectare-scale soil plots at measurement cadences of minutes to hours. CRWI measurements can be used to determine surface soil moisture at a range of desert sites to inform management decisions and to better reveal ecosystem processes in water-limited environments.