Post-transplant lymphoproliferative disease (PTLD) is a well recognized complication of solid organ transplantation and therapeutic immunosuppression, first reported in 1968. PTLD incorporates a spectrum of abnormalities ranging from a benign infectious mononucleosis-like illness to non-Hodgkin's lymphoma with nodal and extranodal site involvement. The first liver transplant was performed at our institution in January 1982. This retrospective study examined the incidence of PTLD, reason for the original transplants, presenting symptoms, radiological findings, immunosuppression regimens and outcomes of these patients. From a total of 2005 adult liver transplants, 23 patients (1.1%) were identified with PTLD. The average age of these patients at the time of transplant was 46.5 years, with a ratio of female-to-male of 14:9. Indication for transplant ranged from primary biliary cirrhosis (eight patients) to epitheloid haemangioendothelioma (one patient). The average time interval between transplant and diagnosis of PTLD was 50 months. Imaging abnormalities identified included generalized lymphadenopathy, liver and portal masses, splenic enlargement, bowel, eye, cerebral and neck involvement; and in two patients, no radiological abnormality. The most common histological findings ranged from B-cell non-Hodgkin's lymphoma (five patients) to early PTLD in one patient. Our rate of PTLD is lower compared with published literature and demonstrates a much longer time interval from transplant to occurrence of PTLD than previously appreciated. This could be secondary to a low immunosuppression therapy followed at our institution. From a few months to several years after liver transplantation, the radiologist needs to be alert to the possibility of PTLD and thorough imaging is required to detect the wide variety of potential presentations.
Esophageal resection is a formidable surgery which is often associated with high morbidity and mortality rate despite an improvement in postoperative care. Fluid administration has been described to be a major factor that contributes to the development of postoperative complications after esophagectomy. The aim was to study the relationship between intraoperative fluid administration and the postoperative hospitalization stay Methods After hospital ethical committee approval, 69 patients who underwent Robotic-assisted esophagectomy dated from January 2011 to till date were accessed from the hospital electronic databank. Single lung ventilation was used in all of the patients during the thoracic approach. 69 patients were divided into two groups with respect to patients in first group who received 4 litres and below and the second group who received 4litres and above of crystalloids. Variables studied were ASA status, demographic data, intraoperative fluids administered, ventilator mode, positioning, postoperative parameters studied were icu stay, sepsis, ionotropic support, respiratory distress, reexploration, readmission to icu. Results None of the variables studied except fluid administration were shown as risk factor. Conclusion Anesthetic regimen directed at a restrictive intraoperative fluid of less than 4 litres has reduced the postoperative morbidity rates and the duration of hospital stay in patients undergoing Robotic esophagectomy.
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