No abstract

Summary 1. A study is made of the extracellular (thiocyanate) space and blood chemistry in 14 cases of severe infantile gastroenteritis. 2. On admission, and in spite of evident dehydration, thiocyanate space was normal in 8 cases, considerably higher than normal in 3, and below normal in 3 cases only. During rehydration thiocyanate space increased regularly, and always unmistakably more than the corresponding gain in weight. While recovery was in progress, the values returned to normal. 3. At the beginning of treatment the potassium concentration of the erythrocytes was lowered in these patients and the sodium concentration increased. A certain correlation could be observed between these values and changes in thiocyanate space. 4. It is suggested on the basis of this study that changes in cellular permeability probably occur in severe infantile gastroenteritis. Résumé 1. On fait une étude de l'espace extracellulaire (thiocyanate) et de la chimie du sang dans 14 cas de gastroentérite infantile grave. 2. A l'admission, et malgré une déshydratation évidente, l'espace thiocyanate était normal dans 8 cas, beaucoup plus élevé que la normale dans 3 cas et au‐dessous de la normale dans 3 cas seulement. Pendant la réhydratation, l'espace thiocyanate a augmenté régulièrement et toujours manifestement plus que l'augmentation correspondante de poids. Pendant que progressait la guérison, les valeurs revenaient à la normale. 3. Au commencement du traitement, la concentration de potassium des érythrocytes de ces sujets était abaissée et la concentration de sodium augmentée. On a pu observer une certaine corrélation entre ces valeurs et les changements de l'espace thiocyanate. 4. Sur la base de cette étude, on présente l'opinion que des changements de la perméabilité cellulaire se produisent probablement dans les cas de gastroentérite infantile grave. Zusammenfassung 1. Die Arbeit enthält eine Studie der extrazellulären (Thiocyanat) Räume und der Blutchemie in 14 Fällen von schwerer infantiler Gastroenteritis. 2. Im Anfang waren die Thiocyanat‐Räume, trotz sichtbarer Eintrocknung, in 8 Fällen normal, in 3 bedeutend grösser, in nur 3 verkleinert. Während der Rehydrierung nahmen die Thiocynat‐Räume regelmässig zu und zwar mehr als der Gewichtzunahme entsprechend, um allmählich wieder normal zu werden. 3. Im Anfang der Behandlung war die Kalium‐Konzentration der Erythrozyten niedrig, die Katrium‐Konzentration erhöht. Eine gewisse Korrelation zwischen diesen Werten und den Veränderungen der Thiocyanate‐Räume wurde nachgewiesen. 4. Es ist auf Grund dieser Befunde wahrscheinlich, dass bei schwerer infantiler Gastroenteritis Veränderungen der Zellen‐Permeabilität eintreten. Resumen 1. Se ha hecho un estudio del espacio extracelular (tiocianato) y de la química de la sangre en 14 casos de gastroenteritis infantil grave. 2. En la admisión, a pesar de una deshidratación évidente, el espacio tiocianato era normal en 8 casos, mucho más elevado que lo normal en 3 casos e inferior a lo normal solamente en 3 casos. Durante la rehidratación, e...

The immunologic efficacy of a corn-combined poliomyelitis-DTP vaccine adbined poliomyelitis, diphtheria, tetanus sorbed on aluminum phosphate and stored and pertussis vaccine has been well for 3 t o 8 months. These are compared

Summary Eighty five children and young persons cured of tuberculous meningitis were reexamined by EEG 6—12 1/2 years after the onset of the disease. Moderate or severe EEG changes were seen in 50 cases, i.e. 59 per cent. The most frequent abnormality found was general dysrhythmia (29 cases) combined with focal abnormalities in 9 cases. Focal abnormalities were seen in the records of altogether 14 former patients. Of these, 9 had convulsions. Repeated EEG examinations were made in 15 cases. Seven of these showed improvement and 1 progression of the disturbances. Abnormal EEGs were seen most frequently among the youngest patients (0—3 years), among patients with severe symptoms on admission and among patients treated with cortisone. Correlation was also found between EEG changes and other sequelae: convulsions, neurological disorders, mental sub‐normality, behaviour disturbances and intracranial calcifications. There were no correlations between EEG abnormalities and late ophthalmological and otological sequelae.

Summary Seventy‐three premature infants have been fed during the first weeks of life through an indwelling nasal polyethylene tube. Eight of them died; the cause of death being cerebral hemorrhage in three cases, congenital malformation of the brain in one case, and immaturity in four cases. The survivors did well and the average hospitalization time was 58 days. The tube was left in for an average period of 17 days, the longest time being 48 days. No complications were encountered. The method is considered to present obvious advantages as compared with the ordinary gavage method and is recommended for use particularly in the treatment of prematures who are very small or in poor condition.