Introduction. The effects of sun exposure on the skin and specifically those related to pigmentation disorders are well known. It has recently been shown that blue light leads to the activation of metalloproteinases, the induction of oxidative stress, and long-lasting pigmentation. The protective effect of the aqueous extract of Polypodium leucotomos (FernblockÒ) is known. Objective. To investigate the action mechanism of FernblockÒ against pigmentation induced by blue light from digital devices. M&M. Human fibroblasts (HDF) and murine melanocytes (B16-F10) were exposed to artificial blue light (a 400-500 nm LED lamp). FernblockÒ was used as photoprotector. Cell viability, mitochondrial morphology and the expression of the mitogen-activated protein kinase (MAPK) p38 as markers involved in the melanogenesis pathway, were evaluated. The activation of Opsin-3, a membrane protein sensitive to blue light that triggers the activation of the enzyme tyrosinase responsible for melanogenesis in melanocytes, was also analyzed. Results. The pretreatment with FernblockÒ prevents cell death, alteration of mitochondrial morphology and phosphorylation of p38 in HDF. In addition, FernblockÒ significantly reduces the activation of opsin 3 in melanocytes and the photo-oxidation of melanin, preventing its photodegradation. Conclusions. The photoprotective role of FernblockÒ could be due to a reduction of the activation of opsin 3 and the formation of the oxidized form of melanin, preventing hyperpigmentation and exerting beneficial effects against the detrimental impact of blue light from digital devices and preventing early photoaging.