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Aim: The most common treatment of HCV is a therapy with interferon a (INF-a), which could escalate appetite problems in patients. The anorexia and liver damage force suffers to adhere to a special diet, which can reduce the negative effects among the participants' interferon therapy. Thus, the aim of this preliminary study was to assess the trace elements nutritional habits in patients with HCV with and without the interferon therapy. Method: The study was carried out in 50 patients with HCV, males (n = 24) and females (n = 26), aged 19-65. 24 persons (12 males and 12 females) were treated by biotherapy of INF-a and ribavirin. For the assessment of trace elements intake a 24-h interview from 3 randomly chosen days fi"om each week of a 6 week study was used. Results: In the assessment of nutritional status, the body mass index (BJVII) as well as general energy intake were lower in all patients with interferon therapy than in those without therapy group. The sodium, potassium, phosphorus, magnesium, calcium, magnesium, iron, copper and zinc intakes were statistically lower in patients with therapy than without and were insufficient. Conclusions: The interferon therapy influences appetite regulation in patients with HCV and the reduction of diet intake can also lead to insufficient mineral intake as well as to symptoms associated with hypomineralemia. This study suggests-multi-supplementation with trace elements in all patients with HCV.

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