OBJECTIVES A higher prevalence and incidence of dementia is found in Hispanic/Latino older adults. Therefore, valid instruments are necessary to assess cognitive functioning in this population group. Our aim was to review existing articles that have examined and reported on the validity of cognitive assessment tools in Hispanic/Latino population groups in the United States. DESIGN Systematic literature review according to the Preferred Reporting Items for Systematic Reviews and Meta‐analysis. MEASUREMENTS We systematically searched in the PubMed and Web of Science databases and assessed the quality of the search results using the Standards for the Reporting of Diagnostic Accuracy Studies. We included evidence from within the United States as well as from Spanish‐speaking countries of origin (Mexico, Central and South America, and the Caribbean). RESULTS The literature search revealed 27 studies with adequate quality that investigated 13 instruments. The Mini‐Mental Status Examination (MMSE) was the most frequently investigated instrument in Hispanic/Latino groups in the United States with high sensitivity for dementia but also with significant differences for ethnicity and education. The Addenbrooke Cognitive Examination‐Revised, Montreal Cognitive Assessment, 10/66 short diagnostic schedule, clock‐drawing test, Phototest, Eurotest, and Executive Battery 25 had good diagnostic performance in Spanish‐speaking countries. The naming test and verbal fluency tests have a higher risk of misclassifying US Hispanics/Latinos who have dementia. CONCLUSION Evidence on validity suggests that the MMSE may be an appropriate cognitive assessment tool for Hispanics. More research is needed to confirm the validity of cognitive tools to assess Hispanic/Latino groups for Alzheimer's disease and other related dementias in the United States to reduce current trends of culturally biased under‐ or overdiagnosis of cognitive impairments. J Am Geriatr Soc 68:882–888, 2020

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