Although preoperative CRT induced high clinical and pathological response, there was no statistically significant benefit in OS and EFS.

No abstract

This study aimed to evaluate changes in the number and clinical characteristics of patients with acute acquired concomitant esotropia (AACE) over the course of 8 years. This retrospective study enrolled patients with AACE who visited our clinic between July 2014 and June 2022. The total study period was divided into 4 periods in chronological order. The number of patients who initially visited the clinic and underwent surgery was compared over time by dividing the time period into 8 quarters (quarters, 2 years). Clinical factors were analyzed between patients with and without surgery. Ninety-seven patients were enrolled (mean age, 29.5 years; 43 females). Among these, 65 patients (67.0%) underwent surgery. The number of patients with AACE increased steadily throughout the study period. The number of patients who underwent surgery was the highest during the 2020 Q3 to 2022 Q2. There was an increasing trend in patients with large ocular deviation (≥30 prism diopters) over time among patients with AACE who underwent surgical treatment (P = .037). Mean ocular deviation at the initial visit was greater in patients who underwent surgery than in those who did not (P < .001). The mean age of patients who underwent surgery was lower than that of patients who did not (P = .005). The number of patients with AACE has been increasing over time. Patients who underwent surgical treatment showed more ocular deviation and were younger at the initial visit than patients who did not.