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Background: With the availability of infliximab, nowadays recurrent Crohn's disease, defined as disease refractory to immunomodulatory agents that has been treated with steroids, is generally treated with infliximab. Infliximab is an effective but expensive treatment and once started it is unclear when therapy can be discontinued. Surgical resection has been the golden standard in recurrent Crohn's disease. Laparoscopic ileocolic resection proved to be safe and is characterized by a quick symptom reduction.
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From March 1, 1991 to December 31, 1994, a total of 76 patients with acute pancreatitis were treated at the surgery division. Out of these, 16 (21%) were treated for necrotizing pancreatitis with open packing and programmed lavage. They were 12 men and 4 women with an average age of 51.5 years. The Ranson score on admission averaged 5.6. The total duration of hospitalization was 58.25 days, the average stay in the intensive care unit 23.7 days. In 6 (37.5%) patients, there were serious surgical complications: pancreas fistulae (n = 5), colon perforations (n = 3) and errosion hemorrhages (n =2). 12 patients developed a cicatricial hernia owing to the laparostoma, and 2 developed diabetes requiring insulin administration after the operation. The hospital mortality was 16.7% (n = 2). Considering the severity of the disease and the initial situation, acceptable results can hence be obtained with the method of open packing and programmed lavage.
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