their arrival in the city, have induced me to include this among my suc¬ cessful inoculations. From the evidence adduced in the preceding pages, I conclude that while yellow fever is incapable of propagation by its own unaided efforts, it may be artificially communicated by inoculation, and only becomes epidemic when such inoculations can be verified by some external natu¬ ral agent, such as the mosquito. The history and etiology of yellow fever exclude from our consideration, as possible agents of transmission, other blood-sucking insects, such as fleas, etc., the habits and geographical distribution of which in no wise agree with the course of that disease: whereas, a careful study of the habits and natural history of the mosquito shows a remarkable agreement with the circumstances that favor or impede the transmission of yellow fever. So far as my information goes, this disease appears incapable of propaga¬ tion wherever tropical mosquitoes do not or are not likely to exist, ceasing to be epidemic at the same limits of temperature and altitude which are incompatible with the functional activity of those insects; while, on the other hand, it spreads readily wherever they abound. From these con¬ siderations, taken in connection with my successful attempts in producing experimental yellow fever by means of the mosquito's sting, it is to be inferred that these insects are the habitual agents of its transmission. It cannot be denied, however, that other such agents may and probably do occasionally occur, but not being endowed with the same facilities for rapid and extensive operation, their influence becomes insignificant as compared with the action of the Cuban culex.
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