A practical synthesis of α,ω‐bifunctional linkers is described that is based on three building blocks, namely, thioctic acid, a spacer‐arm of seven ethylene glycol units, and a functional motif dedicated to the selective immobilization of purposely tagged proteins. Such representative motifs are biotin, haloacetamide, maleimide, and nitrilotriacetic acid derivatives. The building blocks are connected through alkyl, amide, and/or carbamate linkages.

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