We study a three-species cyclic model whose organisms are vulnerable to contamination with an infectious disease which propagates person-to-person. We consider that individuals of one species perform an evolutionary self-preservation strategy by reducing the mobility rate to minimise infection risk whenever an epidemic outbreak reaches the neighbourhood. Running stochastic simulations, we quantify the changes in spatial patterns induced by unevenness in the cyclic game introduced by the mobility restriction strategy of organisms of one out of the species. Our findings show that variations in disease virulence impact the benefits of dispersal limitation reaction, with the relative reduction of the organisms' infection risk accentuating in surges of less contagious or deadlier diseases. The effectiveness of the mobility restriction tactic depends on the tolerable fraction of infected neighbours used as a trigger of the defensive strategy and the deceleration level. If each organism promptly reacts to the arrival of the first viral vectors in its surroundings with strict mobility reduction, contamination risk decreases significantly. Our conclusions may help biologists understand the impact of evolutionary defensive strategies in ecosystems during an epidemic.