Suturing materials are artificial products used for intimate approximation of the wound margins, until they are capable of self-healing with the help of natural collagen fibers. The ideal suture material must have the following characteristics: strength, knot stability, flexibility, easy handling, minimal tissue response and resistance to infection. There is a wide range of suturing materials and they are used in both periodontal surgery and implantology. Today, the number of alternative products that are used as sutures has increased, as well as synthetically produced products. We mainly classify suturing materials as nonresorbable and resorbable. Furthermore, they can be subclassified as natural and synthetic as well as monofilament or multifilament materials. In this review paper we performed an electronic database search and tracked the inflammatory reactions of tissues when using different types of suturing materials. In the paper we have highlighted the more significant trends in new types of sutures. Tissue reactions vary depending on the surface of the materials and the bacterial adhesion to them.