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IN previous work it has been shown that insulin, injected into the normal animal, reduces the amino-nitrogen content of the blood and tissues [Luck et al., 1928; Kiech and Luck, 1928], the latter even though hypoglyeaemia be prevented by the simultaneous administration of glucose [Luck and Spaulding, 1928-29]. The rate of urea formation is also increased. More and more we have come to believe that these effects upon protein metabolism are independent of the effects upon carbohydrate metabolism. In the present paper we wish to adduce additional evidence which leads to this conclusion.

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