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The recent increasing interest in viruses as causative agents in cancer has come about for two main reasons. In the first place tumours can be induced in laboratory animals by an increasing number of viruses, the modes of action of which are not necessarily the same and therefore give us scope for comparative studies. Secondly, the structures and biochemical activities of viruses are clearer now than was believed possible five years ago.

not accompanied by a rise in plasma angiotensin. Actions and interactions of renin, aldosterone and the kidney are discussed by Gross. A method of estimating plasma renin is given by Brown and colleagues. Clinical aspects of aldosterone occupy nearly 200 pages. Primary aldosteronism is re-evaluated by Conn; the difficulty of distinguishing this syndrome from hyperaldosteronism secondary to renal ischvmia is covered by Conn and by Wrong. Liddle's familial syndrome of pseudoaldosteronism appears again. The relationship between aldosterone and human hypertension is reviewed by Genest and by Laragh and their colleagues; and there is a communication by Gerasimova giving a Russian view based on Pavlovian theory. The relationship of aldosterone to oedematous states is discussed by Wolff and by Luetscher and colleagues. Finally, Sims presents studies of aldosterone secretion rate during pregnancy. These papers do not solve many of the current problems of the significance of aldosterone in its physiological and pathological roles. They do, however, cover the whole ground and reveal what workers scattered throughout the world were thinking on this subject in 1963, for the discussions which follow the communications are often as interesting as the papers themselves.

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