Vancomycin is a widely used antibiotic in hemodialysis patients. The main complications include renal toxicity and skin lesions. Herein, we report the case of a 29‐year‐old hemodialysis patient who presented a bullous pruriginous dermatosis after vancomycin treatment. A skin biopsy revealed a linear IgA bullous dermatosis (LABD). This is a rare form of dermatosis and is either idiopathic or more likely vancomycin‐induced. Similarities in the molecular structure of vancomycin and epidermal basement membrane glycoproteins could explain the auto‐immune response. The overall prognosis after drug discontinuation and dermocorticoid treatment was good.