The effect of adrenergic drugs on ovum transport through the oviduct was studied at 24, 36, 48, 60, 72 and 84 hr post coitum (p.c.) in 240 mature, female Dutch-belted rabbits.In untreated rabbits, ova were located in the area of the ampullaryisthmic junction at 24 hr p.c.; most ova entered the uterus between 72 and 84 hr p.c. Epinephrine increased (P<0\m=.\01) the rate of ovum transport at 60 and 72 hr p.c., and most of the ova were found in the uterus. Phenoxybenzamine (\g=a\-blocker) inhibited ovum transport at 48 hr p.c. (P<0\m=.\05), while propranolol (\g=b\-blocker) was ineffective in altering ovum transport in any of the time periods.Regulation of ovum transport through the rabbit oviduct appeared to be governed in part, by a neural-endocrine interrelationship; this relationship could be altered by adrenergic stimulants and blocking agents.

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