Our purpose of this study was to demonstrate the clinical potential and spatial resolution of a new MRI technique: high-resolution blood oxygen-level dependent venography (HRBV), in well-known intracranial vascular lesions, such as cavernous and venous angiomas, and venous sinus thrombosis. HRBV provides unique high-resolution information on veins without administration of contrast medium. The data are independent of conventional findings on MRI and potentially useful in characterising and demonstrating the architecture of vascular lesions of the brain.

MR-Mammography reaches a high sensitivity in detecting breast carcinomas of 3 mm in size at least. In cooperation with the Institute of Diagnostic and Interventional Radiology of the Friedrich-Schiller-University of Jena, a manipulator has been developed by the IMB, which combines the advantages of MRM imaging with a minimal invasive biopsy and a possible subsequent therapy. Referring to this ROBITOM I was introduced in November 1999 as worldwide first, precise operating manipulator system in the ISO center of a closed MR, at RSNA in Chicago. Clinical trials started at 22. November 2000. The experiences and results of these tests were brought into the following prototype ROBITOM II, that is currently developed at the IMB. The completion of this Prototype is planned at the end of 2002.

Quantitative susceptibility mapping (QSM) has been recently introduced as a novel MRI post-processing technique of gradient recalled echo (GRE) data. QSM is useful in depicting both brain anatomy and for detecting abnormalities. Its utility in the context of ischemic stroke has, however, not been extensively characterized so far. In this study, we explored the potential of QSM to characterize vascular and tissue changes in the transient middle cerebral artery occlusion (tMCAO) mouse model of cerebral ischemia. We acquired GRE data of mice brains at different time points after tMCAO, from which we computed QSM and MR frequency maps, and compared these maps with diffusion imaging and multi-slice multi-echo imaging data acquired in the same animals. Prominent vessels with increased magnetic susceptibility were visible surrounding the lesion on both frequency and magnetic susceptibility maps at all time points (mostly visible at > 12 h after reperfusion). Immunohistochemistry revealed the presence of compressed capillaries and dilated larger vessels, suggesting that the appearance of prominent vessels after reestablishment of reperfusion may serve compensatory purposes. In addition, on both contrast maps, tissue regions of decreased magnetic susceptibility were observed at 24 and 48 h after reperfusion that were distinctly different from the lesions seen on maps of the apparent diffusion coefficient and T 2 relaxation time constant. Since QSM can be extracted as an add-on from GRE data and thus requires no additional acquisition time in the course of acute stroke MRI examination, it may provide unique and complementary information during the course of acute stroke MRI examinations.

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