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Gentamicin sulphate was administered to male Wistar rats by intramuscular injection at varying dosage and for varying periods. At high dosage (50-100 mg/kg/day) gentamicin causes tubular necrosis. At dosages equivalent to that given to man (5 mg/kg/day) obvious degenerative changes are produced. Similar changes are seen in human tubular epithelium and urine deposits of patients treated with gentamicin. There is increased excretion of urinary enzymes proportional to the degree of tubular damage. The importance of these changes in man is stressed.

Summary Studies in 30 patients with vesical lesions show that intercellular collagen is present in varying amounts. Pressure flow studies in 4 patients who had undergone vesical overdistension episodes showed full recovery in only 1 patient, with straining micturition in the other 3. In all 4, marked intercellular collagen was found in the bladder biopsies. These changes are similar to those found in the experimental model.

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