This document is the user manual for the Simulation Environment for Radiotherapy Applications (SERA) software program developed for boron-neutron capture therapy (BNCT) patient treatment planning by researchers at the Idaho National Engineering and Environmental Laboratory (INEEL) and students and faculty at Montana State University (MSU) Computer Science Department. This manual corresponds to the final release of the program, Version 1C0, developed to run under the RedHat Linux Operating System (version 7.2 or newer) or the Solaris™ Operating System (version 2.6 or newer). SERA is a suite of command line or interactively launched software modules, including graphical, geometric reconstruction, and execution interface modules for developing BNCT treatment plans. The program allows the user to develop geometric models of the patient as derived from Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) images, perform dose computation for these geometric models, and display the computed doses on overlays of the original images as three dimensional representations. This manual provides a guide to the practical use of SERA, but is not an exhaustive treatment of each feature of the code. iv IN MEMORIAMFloyd J. Wheeler passed away before the final version of the software and manual were completed. Floyd was a leader and innovator in the development of computational methods for neutron transport in tissue, a widely respected member of the international Neutron Capture Therapy community, a great teacher and mentor, a dedicated and loving father, and one of the most decent, forthright, and helpful people anyone could hope to meet. His absence impoverishes us all. v ACKNOWLEDGEMENTSAs with many large endeavors such as this, there is a supporting cast of thousands lurking behind the scenes who are not only unrewarded but, worse, unrecognized. In many of these cases, these same people may and do make contributions more significant than do the authors appearing on that work. This effort is no exception. With regard to this effort, there is one such person that stands above all others, authors included, and that person is Merle Griebenow. Merle instituted the boron neutron capture therapy (BNCT) program at Idaho National Engineering and Environmental Laboratory (INEEL), and perhaps revived it in many other quarters. Merle, like Professor Hatanaka before him, was regarded as a heretic by many of his peers, except by those who really know him. We might say that being regarded as a heretic is perhaps really an honor, since, from the historic perspective, it's probably heresy, not necessity, that is the mother of invention.Merle has an incredible capacity to observe and learn and then trust and support the people he recruits. For that, we are most grateful.
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1 _j This report presents summaries for two months of current research of the Idaho National ._ Engineering Laboratory (INEL) Boron Neutron Capture Therapy (BNCT) Program. Information is presented on development and taurine screening experiments of low-density lipoprotein, carboranyl _ alanine, and liposome boron containing compounds. Pituitary tumor c_ll culture studies are : described. Drug stability, pharmacology and toxicity evaluation of borocaptate sodium (BSH) and : boronophenylalanine (BPA) are described. Treatment protocol development via the large animal (canine) model studies and physiological response evaluation in rats are discussed. Supporting technology development and technical support activities for boron drug biochemistry and purity, analytical and measurement dosimetry, and noninvasive boron quantification activities are included for the current time period. Current publications for the two months are listed.
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