Chemical investigation of the deepwater sponge Macandrewia azorica, collected from the flanks of the Gettysburg and Ormonde Sea Mount, North Atlantic, from a depth of 600 m, has led to the isolation of a new sterol with an unusual side chain (1), along with S-methylergothioneine (2). The structures of compounds 1 and 2 were established by employing spectroscopic techniques (NMR, MS, UV, IR and polarimetry). This is the first report of metabolites of a sponge belonging to the genus Macandrewia.

The cover shows a multiple recolonialization of the calcareous basal skeleton of Spirastrella (Acanthochaetetes) wellsi (Hartman and Goreau 1975).

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Manzacidin D: An Unprecedented Secondary Metabolite from the "Living Fossil" Sponge Astrosclera willeyana. -The title compound (I), an extremely rare type of natural product, is identified together with the known substances norzooanemonin and trigonelline. -(JAHN, T.; KOENIG, G. M.; WRIGHT, A. D.; WOERHEIDE, G.; REITNER, J.; Tetrahedron Lett. 38 (1997) 22, 3883-3884; Inst. Pharm.

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