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A simple kinetic model of the llg-hydroxylation of the 6a-fluor-21-acetoxy-16a-methyl-4-pregnen-3,20-dione was conceived to comprehend the complex processes of an enzymaOic reaction. Although eleven parameters were varied in these experiments, it was possible to simulate the reaction-curves in all cases with the analog computer and to characterise the microbiological processes by only two kinetic parameters.Das Mycel des Pilzstammes Curvularia lunata vermag in waSriger Losung das 6a-Fluor-21 -acetoxylGa-methyl-4-pregiien-3,2O-dion (S) in 11p-Stellung zu hydroxylieren. Das Hauptprodukt beim Einsatz von S ist das unter gleichzeitiger Verseifung entstehende Ga-Fluor-1 $3,21-dihydroxy-16a-methyl-4-pregnen-3,20-dion (P

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