Bilateral ovariectomy resulted in many changes of the degeneration ultrastructural pattern but in none of the characteristic features of the dysjunction pattern. Our results indicate that the mature rodent detrusor and its innervation are sensitive to prolonged ovarian hormonal deficiency, contributing to impaired contractility in rodents. Future studies are required to establish whether estrogen has a role in the degeneration ultrastructural pattern or impaired contractility in humans.

Diagnosis was confirmed by the demonstration of cytoplasmic vacuolation and intranuclear inclusions in epithelial cells, and by observing the virus particles themselves by electron microscopy. Lesions persisted for at least 100 weeks.