The antibacterial effect (ABE) of 97 human semen specimens was tested against Staph. albus, Staph. aureus and E. coli using a disc method. A positive ABE could be shown in 21 specimens. Microzone electrophoresis as well as total protein determination were done from all specimens. Six discernible electrophoretic fractions were observed forming seven different electrophoretic patterns. In addition, semen morphology studies were performed. The demonstrable ABE was shown to be statistically highly significantly inversly correlated to the amount of semen total protein and especially fraction Po.Connecting the findings to a previous study, there seems to be a triangular relationship between ABE, semen proteins and semen morphology. The implications of these findings are discussed as an aspect of ihe antibacterial barrier in the male urethra. Scand J Urol Nephrol7Scand J Urol Nephrol Downloaded from informahealthcare.com by University of British Columbia on 12/11/14For personal use only. Youmans, G. P., Liebling, J. & Lyman, R. Y. 1938. The bactericidal action of prostatic fluid in dogs. J Infecr Dis 63, 117. Scand I Urol Nephrol7Scand J Urol Nephrol Downloaded from informahealthcare.com by University of British Columbia on 12/11/14For personal use only.

This randomized double-blind crossover trial was conducted to assess the effects of prazosin, an alpha 1-adrenoceptor blocking drug, on the voiding of 35 patients with benign prostatic obstruction. Maximum and mean flow rates, residual urine, blood pressure and heart rate were measured at baseline and 2, 4, 6, and 8 weeks after starting the treatment with placebo or prazosin. At 4 weeks the treatments were switched over. The patients filled micturition charts at home and scored their voiding associated feelings. The maximum and mean flow rates increased significantly during prazosin treatment, as also did the maximum and mean voided volumes. Residual urine decreased and voiding improved subjectively but these changes were not statistically significant. Blood pressure was lowered and heart rate increased. Prazosin caused postural dizziness more often than placebo. Prazosin seems to offer an alternative to improve voiding in some patients with prostatic obstruction.

No abstract

In 50 patients with prostatic hyperplasia renal function was examined in regard to 1. Incidence and type of impairment; 2. Correlations between the measures of prostatic hyperplasia and the degree of impairment of renal function; 3. The role of urinary infection in impairment of renal function. In this series tubular function proved to be more impaired than the glomerular filtration rate. No correlation could be found between the measures used to express the degree of prostatic hyperplasia and the impairment of renal function. The reasons for this are discussed. The coincidental urinary infection proved to exert a significantly detrimental effect on renal function. The importance of urinary infection in planning therapy in prostatic hyperplasia is emphasized

The method developed for quantitative culture from tissue homogenate and urine is described and the standard error given. A bacterial count was performed from the enucleated adenoma in 92 cases of benign prostatic hyperplasia. In 82 of the cases an additional bacterial count was made from urine taken at the operation by catheter or puncture. Both the adenomatous tissue and the urine were practically sterile ( < 1 × 10² bacteria per g of tissue and < 1 × 10⁴ bacteria per ml of urine) in 41 out of 82 cases. The next largest group consisted of 24 cases in which the bacterial content of the adenomatous tissue was > 1 x 10² and the bacteriuria > 1 × 10⁴ bacteria per ml. There were, in addition, two small groups with the combination infected adenomatous tissue and sterile urine, and sterile adenoma and infected urine. In the cases with infected adenomatous tissue and significant urinary infection a statistically significant correlation was found between the bacterial contents of the two media. The bacterial content of the adenoma was lower than that of the urine. The result of dipping sterile prostatic adenoma in infected urine showed that the bacterial content of the adenomatous tissue in the cases with infected urine was probably derived from contamination by infected urine at operation. The possibility of an antibacterially active substance in prostatic tissue is discussed.