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Fluoxetine, a selective serotonin uptake inhibitorFluoxetine is a selective serotonin uptake inhibitor in man. Platelets harvested from subjects to whom jiuoxetine was administered (30 The pharmacology of fluoxetine* (Fig. I) has been studied extensively in animals. 9 , 13, 20, 21 It selectively inhibits serotonin uptake in rat brain synaptosomes 20 and platelets,13 prevents pchloroamphetamine-induced depletion of brain serotonin, 9 and appears to be without effects on the noradrenergic system. 20, 21 Its selectivity as an inhibitor of the serotonin uptake pump has Received for publication Oct. 12, 1977. Accepted for publication Dec. 22, 1977. generated considerable interest, and thus fluoxetine has been used as a pharmacologic tool for evaluating the physiologic role of the serotonergic system. There is also interest in using a drug of this type in clinical studies to help elucidate the role of serotonin in the pathophysiology of neuroendocrinologic and psychiatric disorders. We describe the clinical pharmacology of fluoxetine and its effects on the noradrenergic and serotonergic systems in man.