Halofuginone (HAL) and monensin (MON) were effective in controlling coccidiosis in turkey poults when included in the feed at concentrations of 2 and 66 ppm respectively. At 10 and 14 weeks of age, body weight and feed intake were greater in poults given HAL with bambermycins (BAM) than in poults given HAL or MON with bacitracin methylene disalicylate (BAC). Poults given two anticoccidial drugs (MON followed by HAL or HAL followed by MON) weighed more and had a lower feed conversion than poults that received no medication, but no difference was found in the performance of turkeys given one or two anticoccidial drugs. There were no differences in performance whether HAL was used before or after the use of MON. None of the drugs completely suppressed oocyst production. At 11 weeks of age, an increase in the number of oocysts in the droppings was noted following drug withdrawal, but no increase was observed in the number of oocysts in the litter. There was no indication of clinical coccidiosis after drug withdrawal.

No abstract

A novel subunit vaccine, consisting of a highly purified composition of Siderophore Receptor Proteins (SRPs) and Porins derived from Salmonella dublin and Salmonella typhimurium was administered to two groups of lactating cows in a large expansion dairy under controlled conditions.

A total of 20 four-year-old, mixed breed cows were selected from the Kansas State University commercial cow-calf herd for this study. Cows were assigned randomly to one of two treatments: placebo, or E. coli O157:H7 SRP® (Epitopix LLC, Wilmar, MN) vaccination prior to calving. Serum total protein (TP) and serum Escherichia coli O157:H7 SRP® antibody levels (SRP) were measured pre-suckle and at set intervals post-suckle in calves. All 20 cows were negative for fecal shedding of E. coli O157:H7 throughout the study. Vaccination of cows had no effect on calf serum TP level (P > 0.05) compared to controls, however, length of time post-birth had a significant effect on calf serum TP levels (P < 0.001). Failure of passive transfer was recognized as early as six hours post-birth. A vaccine treatment by time post-birth interaction was observed for calf serum SRP® antibody levels (P < 0.01). Calves born to dams vaccinated with E. coli O157:H7 SRP® vaccine had elevated serum SRP antibody titers over time compared to placebo vaccinated calves. This study demonstrated that successful E.coli O157:H7 SRP® antibody passive transfer can occur in beef calves under natural range conditions. This could be the first step toward understanding life cycle immunization strategies against E. coli O157:H7 in cattle, and its effects on shedding of the organism by the animal at the time of harvest.