Bei der durch Mg-arme Ernährung erzeugten Arteriosklerose von Ratten waren im Serum die Konzentrationen von Cholesterin, Triglyceriden und Phosphatiden sowie das Spektrum der verschiedenen Lipoproteine gegenüber Kontrolltieren nicht verändert. Der Gehalt des Serum an freien Fettsäuren war erhöht. Der Serumproteingehalt war besonders durch eine Abnahme der Albumine und y-Globuline verringert. Diese Ergebnisse sind unabhängig vom Gehalt der Mg-armen Nahrung an mehrfach ungesättigten Fettsäuren. Der Gehalt von Cholesterin, Triglyceriden und Phosphatiden in den Aorten und Lebern wurde durch die Mg-arme Ernährung nicht beeinflußt. Eine Störung im Lipidstoffwechsel konnte als Ursache der durch Mg-Mangel bedingten Arteriosklerose ausgeschlossen werden.
Lipid metabolism during a dietary magnesium deficiency.
Studies on artherosclerosis induced by magnesium deficiencyArtherosclerosis was induced in rats by a diet deficient in magnesium. Compared with the non-artherosclerotic controls, the serum concentrations of cholesterol, triglycerides and phospholipids and the spectrum of various lipoproteins were unchanged in the artherosclerotic animals. The concentration of free fatty acids was increased. The serum protein concentration showed a decrease, which was due mainly to decreases in the albumin and y-globulin fractions. These results were not influenced by changes in the levels of polyunsaturated fatty acids in the Mg-deficient diet. The concentrations of cholesterol, triglycerides and phospholipids in the aortas and livers of Mg-deficient rats were the same as in the controls. These results show that Mg-deficiency artherosclerosis cannot be correlated with a disturbance in lipid metabolism.
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