The proposed techniques have demonstrated to be effective in the evaluation of diagnostic imaging workflows. A simulated annealing algorithm was used to optimize the patient admission sequence towards minimizing the total completion and total waiting of patients. The obtained results showed average reductions of 5% on the total completion and 38% on the patients' total waiting time.

Jet identification tools are crucial for new physics searches at the LHC and at future colliders. We introduce the concept of Mass Unspecific Supervised Tagging (MUST) which relies on considering both jet mass and transverse momentum varying over wide ranges as input variables — together with jet substructure observables — of a multivariate tool. This approach not only provides a single efficient tagger for arbitrary ranges of jet mass and transverse momentum, but also an optimal solution for the mass correlation problem inherent to current taggers. By training neural networks, we build MUST-inspired generic and multi-pronged jet taggers which, when tested with various new physics signals, clearly outperform the variables commonly used by experiments to discriminate signal from background. These taggers are also efficient to spot signals for which they have not been trained. Taggers can also be built to determine, with a high degree of confidence, the prongness of a jet, which would be of utmost importance in case a new physics signal is discovered.

Dynamic contrast-enhanced magnetic resonance (DCE-MR) of the breast is especially robust for the diagnosis of cancer in high-risk women due to its high sensitivity. Its specificity may be, however, compromised since several benign masses take up contrast agent as malignant lesions do. In this paper, we propose a novel method of 3D multifractal analysis to characterize the spatial complexity (spatial arrangement of texture) of breast tumors at multiple scales. Self-similar properties are extracted from the estimation of the multifractal scaling exponent for each clinical case, using lacunarity as the multifractal measure. These properties include several descriptors of the multifractal spectra reflecting the morphology and internal spatial structure of the enhanced lesions relatively to normal tissue. The results suggest that the combined multifractal characteristics can be effective to distinguish benign and malignant findings, judged by the performance of the support vector machine classification method evaluated by receiver operating characteristics with an area under the curve of 0.96. In addition, this paper confirms the presence of multifractality in DCE-MR volumes of the breast, whereby multiple degrees of self-similarity prevail at multiple scales. The proposed feature extraction and classification method have the potential to complement the interpretation of the radiologists and supply a computer-aided diagnosis system.

In this paper, a Maximum a Posteriori Reconstruction algorithm is applied for the first time to the Siemens 3TMR−BrainPET scanner. The implementation of this algorithm is done in the PET REconstruction Software TOolkit. This software is able to cope with 3D PET listmode data and can deal with the specificities of the Siemens 3TMR−BrainPET scanner. Simulated data was used to assess the performance of the algorithm. Several a priori distributions were tested and the results are compared to OSEM reconstruction. Simultaneously acquired PET and MR data of a human patient was used to show the feasibility of the Maximum a Posteriori algorithm. The results are promising and expected to improve clinical applications.Index Terms-Maximum a Posteriori, Reconstruction, PRESTO, 3TMR-BrainPET.