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It could be involved in regulation ...." Perhaps this indicates regulation by utilisation of the proton generatedbut I would have liked to read an authoritative discussion of this paradox. Firmer editing would have made for easier reading. Many of the authors are not native English speakers. There is no consistency in transatlantic spelling (for example, "uraemia" and "uremia"). Above all, each author uses his own chemical terminology and, sometimes multiple, abbreviations. On one page the section is headed "otKG Metabolism"presumably referring to e-ketoglutarate-cand yet the first article in the section talks of ot-oxoglutarate. One wonders who will buy this expensive book. Specialists would be better served by a much cheaper compilation of the papers; non-specialists will find much repetition and little to interest them. JOAN F ZILVA