Two mice of the TM strain, maintained on Purina chow supplemented with refined corn oil plus free fatty acids, in one case, and with refined corn oil without free fatty acids, in the other case, developed primary heart rhabdomyosarcomas. The tumors metastasized to the lungs and the kidney, in the first case, and to the lungs alone in the second case. One mouse of the TM strain, on the diet supplemented with corn oil plus free fatty acids, developed a fibrosarcoma behind the right anterior extremity. Metastases from the tumor were found in the liver, lungs and myocardium. Another mouse of the C57 Bl. strain, injected subcutaneously, in the interscapular region, at the age of 7 days, with a single dose of 30 μg of Delestrogen, developed, at the point of injection, a large rhabdomyosarcoma. At the age of 533 days, when the animal was killed, metastases from the tumor were found in the intercostal muscles and in the heart. Three mice, one of the TM strain, on a diet supplemented with corn oil and cholesterol, and two of the C57 Br. strain, on a diet supplemented with raw egg yolk (rich in cholesterol) had organized blood clots in the atria (in two mice) and one extending into the ventricle.

HeLa cells Z n + + reversed inhibition of alkaline phosphatase by glycine. Low concentrations of this cation were found to reactivate dialyzed preparations of the same enzyme. Mg+ + retarded thermal inactivation of alkaline phosphatase. Delay in heat inactivation was observed in alkaline phosphatase preparations from both prednisolone treated and control cultures of HeLa cells.

No abstract

Mice of three strains were used in the present experiments. The control mice (group 1, 7 and 9) have been kept on Purina chow only. For the experimental mice of the T. M. strain the Purina chow was supplemented with refined corn oil (group 2), crude corn oil (group 3), refined corn oil plus free fatty acids (group 4), Monoolein (group 5) and Monostearin (group 6). For the experimental mice of the BALB/c and C57 Br. strains (group 8 and 10) Purina chow was supplemented with raw egg yolk. Very few of the control mice developed tumors of the forestomach (3/195 mice in group 1 and 1/165 mice in group 9) and none of them developed pyloric or intestinal tumors. Among the mice maintained on the fat-enriched diets the incidence of tumors of the forestomach and of the pyloric glandular part of the viscus was relatively high, except for the mice in group 6, maintained on Purina chow supplemented with monostearin. Intestinal tumors were found only in mice of the BALB/c and C57 Br. strains maintained on Purina chow supplemented with egg yolk. The tumors were for the most part polyps, except for adenocarcinomas developed by three C57 Br. mice from group 10. The difference between mice of the T. M. strain, (which did not develop intestinal tumors), and those of the BALB/c and C57 Br. strains, (which developed intestinal tumors), may be due to a difference in their susceptibility or to the difference in their diets.

l'innervation primitive du coeur chez les embryons d'Oiseaux (Canard et Poulet)." Revue suisse de zoologie 43, 1-23.