The synthesis of the four silicon analogues of acyclonucleosides was described. In every case, the silicon atom was introduced onto an allyl group on the natural nucleobase following a hydrosilylation reaction. Diols obtained were protected as 4,4′-dimethoxytrityl ethers and subsequently activated as 2-cyanoethyl N,N-diisopropylchlorophosphoramidite in order to be suitable for oligonucleotide solid phase synthesis.

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Synthesis of Silicon Analogues of Acyclonucleotides Incorporable inOligonucleotide Solid-Phase Synthesis. -The novel phosphoramidites (I) are prepared in order to test their use in solid phase oligonucleotide synthesis and to study the properties of resulting oligonucleotides. -(THIBON, J.; LATXAGUE, L.; DELERIS, G.; J.