No abstract

Adult male and female Wistar rats were equally susceptible to gastric injury induced with acetylsalicylic acid (aspirin). Both in male and in female rats simultaneous administration of caffeine and aspirin caused significantly more gastric erosions than the same dose of aspirin alone; likewise addition of paracetamol to aspirin decreased the incidence of gastric lesions in either sex, and addition of phenacetin to aspirin had no effect. The potentiation by caffeine and the inhibition by paracetamol were both dose‐dependent and only markedly influenced the development of erosions after 3–4 h. Pretreatment with phenacetin or paracetamol 1 h before administration of aspirin did not affect its erosive activity. Administration of benorylate caused no more gastric erosions than the vehicle or than equivalent mixtures of aspirin and paracetamol. The histamine‐stimulated acid output of the stomach during gastric perfusion with aspirin was rapidly diminished. Neither paracetamol nor caffeine initially affected this decrease in acid output. However, 30 min after perfusion with aspirin and caffeine, acid secretion increased approximately as strongly as after caffeine alone. Caffeine potentiates aspirin‐induced erosions by its stimulatory effect on acid secretion whereas paracetamol inhibits these erosions by preventing their growth.

The preparation and anthelmintic properties of isopelletierine and four side-chain homologues are described. The compounds were prepared from PI-piperideine and 3-0x0-acids at pH 4-5. PK'~-and Rf-values were determined.Anthelmintic activity as tested in v i m on the liver fluke, by three methods, was highest for 1 -(2'-piperidyl)butanone-2. The differences in anthelmintic properties of the compounds are discussed.

No abstract

Butyl hydroxy toluene reduced gastric erosion due to acetylsalicylic acid in the rat, but not the antiinflammatory, anti-pyretic and analgesic activity. By itself, BHT exhibited activity only in the test on analgesia.