Background: Few studies have estimated the burden of infections due to antimicrobialresistant (AMR) pathogens in China. Aim: To summarize antimicrobial resistance and assess the frequency of communityassociated infections (CAIs) and healthcare-associated infections (HCAIs) due to AMR pathogens in Dongguan city, China. Methods: Seven acute care hospitals provided antimicrobial susceptibility data for 2017, from which 'bugedrug' combinations were analysed. To calculate incidence proportions of CAI and incidence densities of HCAI, data from three tertiary care hospitals were merged with patient data, obtained from the Dongguan Nosocomial Infection Surveillance System. Findings: A total of 16,548 pathogens were analysed. Non-susceptibility to thirdgeneration cephalosporins (3GCs) in Escherichia coli and Klebsiella pneumoniae was 43.9% and 30.2%, respectively. Non-susceptibility to carbapenems in Pseudomonas aeruginosa and Acinetobacter baumannii was 29.5% and 50.9%, respectively. A quarter of Staphylococcus aureus (26.3%) were non-susceptible to oxacillin. The incidence density of HCAI due to E. coli non-susceptible to 3GCs and fluoroquinolones combined was 0.09 (95% confidence interval: 0.07e0.11) per 1000 patient-days. Both E. coli and K. pneumoniae were the predominant pathogens isolated from blood.

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