No abstract

Serological activity in 62 patients wih dermatophytosis was investigated using purified trichophytin preparation as antigen (produced by the ethylene glycol method). Antibodies of IgG and IgM classes were determined by means of ef enzyme linked immunosorbent assay (ELISA). In comparison with 79 controls consisting of groups of healthy blood donors and dermatological outpatients, the dermatophyte-infected patients showed a significantly higher mean IgG response to trichophytin antigen preparation. On the other hand several individual cases were low responders. In a group of 10 control children, no IgG activity against trichophytin could be demonstrated. IgM class antibodies showed no significant differences between the groups investigated. These findings indicate that differences in the amounts of antibodies of IgG class against trichophytin as measured by the ELISA method reflect differences in the degree of mycotic sensitization between groups of individuals having experienced varying degrees of exposure to dermatophytes. Nevertheless, the determination of IgG antibodies in dermatophytosis seems to be of limited clinical value.

No abstract

cancer bearing patients show this change is unknown. Repeated observations on patients at risk of developing metastases or recurrence, however, indicate that transient rises of serum muramiidase are not an uncommon feature in this group of patients. Only time will tell if such rises have any real prognostic significance.

Guinea pigs were immunized with homologous thyroglobulin in complete Freund’s adjuvant or BCG and killed tubercle bacilli. Their sera contained γ₂-globulin, which in the presence of specific antigen inhibited in vitro the migration of blood leukocytes from nonimmunized animals. The γ₁-globulin fraction did not. The relationship between the inhibitory activity of the two globulins and their hemagglutination titers was studied.