Using a motorized treadmill the study investigated the effects of the ingestion of 3 g of caffeinated coffee on: the time taken to run 1500 m; the selected speed with which athletes completed a 1-min 'finishing burst' at the end of a high-intensity run; and respiratory factors, perceived exertion and blood lactate levels during a high intensity 1500-m run. In all testing protocols decaffeinated coffee (3 g) was used as a placebo and a double-blind experimental design was used throughout. The participants in the study were middle distance athletes of club, county and national standard. The results showed that ingestion of caffeinated coffee: decreases the time taken to run 1500 m (P < 0.005); increases the speed of the 'finishing burst' (P < 0.005); and increases Vo2 during the high-intensity 1500-m run (P < 0.025). The study concluded that under these laboratory conditions, the ingestion of caffeinated coffee could enhance the performance of sustained high-intensity exercise. Keywords: Caffeine, ergogenic acid, Vo2, blood lactate Caffeine has long been considered as a substance capable of enhancing performance or physiological functions1 and as a result of its reported ergogenic effects, the International Olympic Committee (IOC) have banned the use of high levels of caffeine. However, since caffeine is commonly found in many foods that are taken as part of the 'normal' diet, when testing for the drug the banned level is set above 15 ig ml-1 urine which is reported to represent the ingestion of 500-600 mg of caffeine (five to six cups of coffee) in a 1-2 h period2. Therefore in practical terms this dosage is only likely to be exceeded through the use of tablets, injections, suppositories or the deliberate ingestion of large amounts3. medulla increasing the secretion of catecholamines; the release of calcium ions from the sarcoplasmic reticulum; and the oxidation of free fatty acids which would produce a glycogen-sparing effect during prolonged exercise.Research into the effects of caffeine has tended to concentrate upon endurance activities such as marathon running or prolonged cyclingI7, with other investigations studying its effects upon maximal strength and power8 9. However, relatively little research has looked at the effects of caffeine upon high-intensity prolonged exercise, where the relative importance of the different physiological parameters required to produce a high level of performance and the physiological causes of fatigue can differ from those of endurance and short-term high-intensity exercise.The aim of this investigation was therefore to study the effect(s) of low doses of caffeine (approximately equivalent to the amount found in two strong cups of coffee) on a number of factors during prolonged high-intensity exercise. The study utilized doses of caffeine that would realistically be ingested by a sports performer before exercise as part of their 'normal' dietary habits without contravening the doping control regulations. Materials and methods

There is little published data in relation to the effects of caffeine upon cycling performance, speed and power in trained cyclists, especially during cycling of approximately 60 s duration. To address this, eight trained cyclists performed a 1 km time-trial on an electronically braked cycle ergometer under three conditions: after ingestion of 5 mg x kg-1 caffeine, after ingestion of a placebo, or a control condition. The three time-trials were performed in a randomized order and performance time, mean speed, mean power and peak power were determined. Caffeine ingestion resulted in improved performance time (caffeine vs. placebo vs. control: 71.1 +/- 2.0 vs. 73.4 +/- 2.3 vs. 73.3 +/- 2.7 s; P = 0.02; mean +/- s). This change represented a 3.1% (95% confidence interval: 0.7-5.6) improvement compared with the placebo condition. Mean speed was also higher in the caffeine than placebo and control conditions (caffeine vs. placebo vs. control: 50.7 +/- 1.4 vs. 49.1 +/- 1.5 vs. 49.2 +/- 1.7 km x h-1; P = 0.0005). Mean power increased after caffeine ingestion (caffeine vs. placebo vs. control: 523 +/- 43 vs. 505 +/- 46 vs. 504 +/- 38 W; P = 0.007). Peak power also increased from 864 +/- 107 W (placebo) and 830 +/- 87 W (control) to 940 +/- 83 W after caffeine ingestion (P = 0.027). These results provide support for previous research that found improved performance after caffeine ingestion during short-duration high-intensity exercise. The magnitude of the improvements observed in our study could be due to our use of sport-specific ergometry, a tablet form and trained participants.

No previous studies have examined the effects of isometric training intensity upon resting blood pressure (BP). The aims of this study were (a) to compare the effects of leg isometric training, performed at two intensities, upon resting systolic-SBP, diastolic-DBP and mean arterial-MAP BP; and (b) to examine selected cardiovascular variables, in an attempt to explain any changes in resting BP following training. Thirty-three participants were randomly allocated to either control, high- (HI) or low-intensity (LI) training for 8 weeks. Participants performed 4 x 2 min exercise bouts 3x weekly. Resting BP was measured at baseline, 4-weeks and post-training. SBP, DBP and MAP fell significantly in both groups after training. Changes were -5.2 +/- 4.0, -2.6 +/- 2.9 and -2.5 +/- 2.2 mmHg [HI]; -3.7 +/- 3.7, -2.5 +/- 4.8 and -2.6 +/- 2.5 mmHg [LI] for SBP, DBP and MAP, respectively. There were no significant changes in BP at 4 weeks. No significant changes were observed in any of the other cardiovascular variables examined. These findings suggest that isometric training causes reductions in SBP, DBP and MAP at a range of exercise intensities, when it is performed over 8 weeks. Furthermore, it is possible to reduce resting BP using a much lower isometric exercise intensity than has previously been shown.

This is the first evidence of durable BP reduction and wider cardiovascular disease risk benefits of IET in a relevant patient population. Our findings support the role of IET as a safe and viable therapeutic and preventive intervention in the treatment of hypertension.

Background: Previous meta-analyses based on aggregate group-level data report antihypertensive effects of isometric resistance training (IRT). However, individual participant data meta-analyses provide more robust effect size estimates and permit examination of demographic and clinical variables on IRT effectiveness. Methods: We conducted a systematic search and individual participant data (IPD) analysis, using both a one-step and two-step approach, of controlled trials investigating at least 3 weeks of IRT on resting systolic, diastolic and mean arterial blood pressure. Results: Anonymized individual participant data were provided from 12 studies (14 intervention group comparisons) involving 326 participants (52.7% medicated for hypertension); 191 assigned to IRT and 135 controls, 25.2% of participants had diagnosed coronary artery disease. IRT intensity varied (8–30% MVC) and training duration ranged from 3 to 12 weeks. The IPD (one-step) meta-analysis showed a significant treatment effect for the exercise group participants experiencing a reduction in resting SBP of −6.22 mmHg (95% CI −7.75 to −4.68; P < 0.00001); DBP of −2.78 mmHg (95% CI −3.92 to −1.65; P = 0.002); and mean arterial blood pressure (MAP) of −4.12 mmHg (95% CI −5.39 to −2.85; P < 0.00001). The two-step approach yielded similar results for change in SBP −7.35 mmHg (−8.95 to −5.75; P < 0.00001), DBP MD −3.29 mmHg (95% CI −5.12 to −1.46; P = 0.0004) and MAP MD −4.63 mmHg (95% CI −6.18 to −3.09: P < 0.00001). Sub-analysis revealed that neither clinical, medication, nor demographic participant characteristics, or exercise program features, modified the IRT treatment effect. Conclusion: This individual patient analysis confirms a clinically meaningful and statistically significant effect of IRT on resting SBP, DBP and mean arterial blood pressure.