AIM:To investigate the effect of oral administration of camel milk on liver enzymes, total proteins and histology of poloxamer 407 induced hyperlipidaemic wistar rats.MATERIAL AND METHODS:Thirty male wistar rats weighing between 150-200 g were randomly assigned into six groups of five each; group I: administered distilled water, group II: induced with P407, group III: induced with P407 and treated with atorvastatin (20 mg/kg) and groups IV, V and VI: induced with P407 and treated with camel milk 250 mg/kg, 500 mg/kg and 1000 mg/kg respectively. After three weeks, blood samples and liver tissues were collected for the determination of alkaline phospatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, albumin/globulin ratio and histological studies respectively.RESULTS:All camel milk treated groups showed significant (p < 0.05) decrease in ALT and AST. Camel milk treated groups; 250 mg/kg and 1000mg/kg showed significant (p < 0.05) decrease in total protein, globulin with all camel milk treated groups having significant (p < 0.05) increase in A/G ratio. Histological examination of liver tissues showed that camel milk at a dose of 250 mg/kg had slight adipocytes infiltration.CONCLUSION:The results of our findings highlight the hepatoprotective effect of camel milk in poloxamer 407 induced hyperlipidaemic wistar rats.

Chlorpyrifos (CPF) has been associated with cognitive and psychomotor impairments in both humans and animals. This cognitive impairment has been linked to its enhanced reactive oxygen species (ROS) generating capacity. Therefore, antioxidant treatment may provide a novel therapeutic window for the management of these related impairments. The aim of this work was to evaluate the beneficial role of resveratrol on chlorpyrifos-induced cognitive impairment and lipid peroxidation biomarker in Swiss albino mice. Swiss albino mice were divided into (6) six groups of five each (n=5). Group I served as the control and were administered olive oil (2 ml/kg), group II received carboxymethylcellulose (CMC) 10 mg/kg, group III received resveratrol 30 mg/kg, group IV received chlorpyrifos (CPF) 3 mg/kg, group V received CPF (3 mg/kg) after the oral administration of resveratrol (30 mg/kg) and group VI received Vitamin E (Vit E) 100 mg/kg All administrations were done by oral gavage for a duration of 21 days. Cognitive function was assessed using Y-maze,and Novel object recognition tests and oxidative stress was evaluated using oxidative biomarkers techniques.The results obtained showed that resveratrol at dose 30 mg/kg significantly(p<0.05) improved cognitive impairment and significantly decreased (p<0.05) malondialdehyde (MDA) concentration when compared with the control. In conclusion, 30mg/kg resveratrol suppressed memory impairment, decreased malondialdehyde levels, increased catalase activity, superoxide dismutase activity and glutathione levels in our chlorpyrifos-induced cognitive impairment mice model.

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Carbamazepine (CBZ) as a drug used in the treatment of epilepsy and neuropathic pain has been shown to facilitate the effects of free radicals. Resveratrol (RESV), known as 3,5,4′-trihydroxystilbene, is found in grapes and other plant products. It effectively scavenges free radicals and other oxidants. Vitamin E (Vit E) is a lipid soluble antioxidant present in all cellular membranes. The present study assessed the combined effect of vitamin E and resveratrol on hematological markers of carbamazepine-induced oxidative stress. Adult male Wistar rats (n = 25) were randomly allotted to five groups: Group I (control) received distilled water, Group II received CBZ (50 mg/kg), Group III received CBZ(500mg/kg) and Vitamin E (200 mg/kg); Group IV received of CBZ(50 mg/kg), and resveratrol (20 mg/kg); Group V received CBZ (50 mg/kg) and the coadministration of vitamin E (200 mg/kg) and resveratrol (20 mg/kg). Administration was done orally daily for 45 day after which animals were sacrificed and blood samples were used for biochemical analyses. Hematological parameters such as Red Blood Cell Count (RBC), White Blood Cell Count (WBC), Platelets Count (PC) and Osmotic Fragility (OF) were determined. Combination of RESV and Vit E significantly increased RBC, WBC PCV and decreased OF compared to the CBZ, RESV and Vit E treated groups respectively. In conclusion, co administration of RESV and Vit E resulted in better protective effect on CBZ induced hematological changes in rats than their respective doses of RESV and Vit E.

Objective: The study investigated changes in haemostatic parameters such as; bleeding time, blood clotting time and differential platelet counts of wistar rats following repeated administration of aqueous extract of allum cepa L. Methods: Rats were divided into four groups of four animals each (n=4). Group I served as normal control, Group II, group IIIand group IV were administered 25 mg/kg bw, 50 mg/kg bw and 100 mg/kg bw of the extract intra-peritoneally for two weeks, respectively. After 14 d experimental period, blood samples were collected for the determination of bleeding time, clotting time and differential platelet count. Results: The findings of this study revealed a significantly increased (p<0.05) clotting time at a dose of 25 mg/kg but showed no significant change in bleeding time and differential platelet count of all the groups. Conclusion: Aqueous extract of brown onion showed anti haemostatic effect in albino rats by increasing clotting time at a lower dose.