Women with sickle cell anemia (SCA) have higher rates of diminished ovarian reserve (DOR) than age-matched controls. Pecker et al report a small study of patients with SCA that compares ovarian reserve in patients after stem cell transplant, on therapy with hydroxyurea (HU), and on supportive care. As expected, patients who received transplants have severe DOR. About one-third of patients on HU have DOR, while DOR was absent in patients on supportive care. Whether this reflects an impact of HU or is a biomarker of severe disease remains to be established in a larger study.

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BACKGROUND:Refractive error is the second leading cause of treatable blindness. 46.69% of all ocular morbidity in the country is directly attributed to refractive errors and myopia is the commonest type of refractive error. School age children constitute a particularly vulnerable group because uncorrected refractive errors may lead to amblyopia, subnormal binocularity or strabismus resulting in permanent visual loss. Studies have shown that there has been an increase in the proportion of myopia among students. In view of the importance of detecting the eye defects in school children in our region where staple food and socio-demography is different from rest of the country an effort has been made in the present study to find out the extent of problem of refractive errors particularly Myopia among school children. OBJECTIVES: To study and evaluate Myopia among School children. METHODS: A cross-sectional study on random control sample of school children of 7-15 year was carried out in the Hubli city. Visual acuity tests were done all students.Students with 6/6 (p) or less vision were subjected for slit lamp examination, retinoscopy, fundus examination, keratometry and A-scan. RESULTS: 13.5% of children had refractive errors. 4.54% had Myopia. Myopia was more common in females with a peak in 13-15 year group. CONCLUSION: Significant proportion of children of this area had uncorrected refractive errors. Regular screening and correction of refractive error will help to improve vision, prevent further deterioration and hence irreversible changes in the visual system.