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Introduction: Atherosclerosis is associated with increased inflammatory activity and risk of vascular disease. The hypothesis is that, the hs-CRP testing might have prognostic usefulness for patients with CAD. Considering a major role of hs-CRP in atherothrombosis, its measurements can provide a novel method to detect individuals at high risk of rupture of plaque. Aim of the Work: This study was performed to find out the relation of high sensitive CRP (hs-CRP) with angiographically proved coronary artery disease (CAD) and its severity. Methodology: Total 125 patients underwent CAG in present study, of them 36% were females and 64% were males, predominated by male sex (‘p’ <0.001. Results: The mean for hs-CRP levels was 1.67(±0.85) mg/L and significantly high in patient with CAD. Strong correlation was formed between age ≥ 45 years and hs-CRP 1-3 mg/ L in present cohort of CAD. About one third of population with CAD had dyslipidemia of them majority (2/3rd) had hs-CRP 1-3 mg/L. Two-third of patients with CAD with tobacco consumption in any form had hs-CRP 1-3 mg/L and was significant than < 1 mg/L and >3 mg/L hs-CRP level. The hs-CRP level associated favorably with the frequency and extent of the CAD in present study (r=0.664). Conclusion: High sensitive CRP offers better risk stratification, predictive and prognostic value, in patients with CAD. Further studies and interventions are mandatory to identify the independent role of hs-CRP as a CAD risk factor and its cost effectiveness in a population of a developing country like India.

Organophosphorus (OP) is an easily accessible pesticide which has a high morbidity and mortality on human exposure. Serum cholinesterase (SChE) is usually used for assessing the severity of poisoning, in this study we assess the role of serum creatine phosphokinase (CPK) as an alternative prognostic marker. This was a single centred, hospital-based, prospective and observational study, conducted on 88 patients with a history of OP compound consumption who were admitted to the ICU of tertiary care hospital, from the time period October 2019 to March 2021.  The patients were clinically categorized into mild, moderate and severe categories according to Peradeniya Organophosphorus Poisoning (POP) scale and before initiation of treatment, the samples were sent for estimation of SChE and serum CPK.  Out of the 88 patients, OP poisoning was more common in the age group of 21-30 years and males had a higher incidence. Chlorpyriphos (62.5%) was the most common compound. A higher POP score, marked reduction in SChE levels, and increased serum CPK levels were observed to have increased the duration of hospital stay, increased the severity of poisoning, increased the need for ventilator support and also increased the mortality.

After coronary illness and all malignancies stroke is the third basic reason for death on the planet.study was aimed to determine the possible relationship between mean corpuscular volume and thrombotic stroke in young people. The study was carried out at a tertiary care hospital. The case-control study was done in 50 patients of young thrombotic cerebrovascular disease and 50 healthy age  and sex-matched controls. Estimation of MCV levels was done in both the groups and compared. The mean age  of cases was 41.56 ± 9.51. total of 50 cases of young stroke, 36 (72%) was male. The mean and SD values of MCV levels for the case group were 96.78±7.54, for the control group were 82.07±7. Out of the 50 young stroke patients, 17 (34%) had MCV levels ≥101fL. In the control group, all the subjects had MCV levels ≤ 100fL. The mean haemoglobin level was 14.29, with SD ± 1.48 in cases, and the control group mean haemoglobin level was 12.41 with SD±1.39. Mean serum haemoglobin levels were higher in cases than controls. The Significant Macrocytosis (MCV≥100fL) can be a new, low cost and early marker in anticipating the risk of developing thrombotic stroke in young adults who may or may not have anaemia.