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Daily subcutaneous injection of 6-dimethylamino purine, 3-amino-d-ribose, an aminonucleoside related to "puromycin."$ ( 1) into immature male rats for 10 to 12 days results in generalized edema, ascites? marked proteinuria, hypoproteinemia, hyperlipemia, and azotemia. The clinical complex and renal pathology closely resemble the nephrotic syndrome occurring in children. This initial report describes the renal lesions and electrolyte composition of edematous tissues in the rat. The observations indicate that the renal lesion involves both the glomerulus and the convoluted tubule: that skin, an essentially extracellular phase tissue, is the largest tissue reservoir for edema fluid; and that the electrolyte structure of muscle cells is only slightly altered during edema.Thirty-six 40 g male rats of Sprague-Dawley strain were caged individually and pair-fed on a standard synthetic diet containing 16% W AV vitamin-free casein. After a preliminary adjustment period, 18 rats (experimental group) were injected daily with 0.003 ml of a 0.5% aqueous solution of the drug per gram of body weight for 12 days. The control rats were injected with similarly calculated doses of distilled water. Twelve animals in each group were given an oral load of M / l NaC1 solution daily by stomach tube in a dose of 1 mM/100 g of body weight for the last 4 days of injection. All animals were sacrificed 24 hours after the last injection. At the time of sacrifice under Evipal anesthesia the hair was carefully Procedure.

Of 824 women screened, 410 were enrolled at midpregnancy in a prospective, randomized, controlled nutrition intervention study. Of these, 226 were predicted as likely to have small or large babies, 184 to have average-sized babies. Two hundred thirty eight mothers received USDA Women, Infants and Children (WIC) Food Supplementation vouchers from midpregnancy, 172 did not. Leukocyte protein synthesis (as a cell model) was significantly higher (p = 0.009) by 36 weeks gestation in supplemented mothers. Mean birth weight of their babies was greater, 3254 vs 3163 g, (+91 g) p = 0.039, adjusted for sex, gestational age, prenatal visits, pregnancy interval, smoking, and previous low birth weight infants. Controlling for entry weight obviated the significance of the difference, except for WIC supplemented smokers (greater than 10 cigarettes/day) whose babies were significantly heavier by +168 g (p = 0.017) than those of unsupplemented smokers. WIC partially protects fetal growth in smokers.

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