Background Serious bacterial infections may be missed when all attention focuses on COVID-19. It is therefore important to consider bacterial infection when assessing the febrile patient.Aims The aim of the study was to look at the bacterial and fungal co-infections, antimicrobial treatment and clinical outcome in COVID-19 patients in an acute Irish hospital.Methods A retrospective study of all laboratory confirmed COVID-19 cases admitted to a secondary care university hospital was performed, and clinical, radiology and laboratory data was extracted and analysed.Results 42 patients met eligibility criteria for the study inclusion. Male/female ratio was 22/20 (52.4%/47.6%), median age of the patients was 64 years and the median duration of hospital stay was 11 day. In-hospital mortality rate was 3 (7.1%). Four laboratory confirmed co-infections were identified in 3 (7.1%) patients. All 3 patients were discharged home. Out of 42 patients, 12 (28.6%) patients received specific antiviral treatment. 34 (85.0%) patients were prescribed antimicrobials with antibacterial effect and 3 (7.5%) antimicrobials with antifungal effect.Conclusions We found a low frequency of bacterial and fungal co-infections in confirmed COVID-19 cases. Further prospective data are needed to be collected in relation to the co-infections in COVID-19.