Background: Rabbitbrush ( Ericameria nauseosa) is a conspicuous member of plant communities in the deserts of western North America. The plant is an important winter forage for several ungulates in the region and has been used in Native American ethnopharmacology. Methods: Several specimens were collected from North Central Utah (8 samples) and Southwestern Idaho (6 samples). The essential oils were obtained by hydrodistillation and analyzed by gas chromatographic techniques. The data were analyzed using agglomerative hierarchical cluster analysis (HCA), principal component analysis (PCA), and Pearson correlation analysis. Results: Essential oil yields ranged from 0.030% to 2.011%. The major components in the essential oils were β-phellandrene (1.8%-56.5%), β-pinene (0.%3-23.3%), limonene (0.7%-22.3%), and ( Z)-β-ocimene (0.0%-29.3%). With the exception of 1 sample from Utah, the essential oils showed greater than 50% similarity in composition. There were significant differences in percentages of some components, however. Sabinene, β-phellandrene, cosmene, 1,3,8- p-menthatriene, terpinen-4-ol, and β-eudesmol concentrations were higher in the Idaho samples while myrcene, limonene, geranyl acetate, ( E)-β-caryophyllene, γ-curcumene, germacrene D, α-muurolene, γ-cadinene, and δ-cadinene concentrations were significantly higher in the Utah samples. Chiral gas chromatography–mass spectrometry showed the chiral monoterpenoids to be dominated by the (−)-enantiomers, but there were some differences in enantiomeric distribution in the essential oils from Utah compared to those from Idaho. Conclusion: The essential oil compositions in this work are qualitatively similar to those reported previously. However, there were quantitative differences in chemical composition and enantiomeric distributions between the Utah samples and the Idaho samples. Additional research is needed to compare essential oil composition from other geographical locations in western North America.