Studies have shown that cigarette smoking is a risk factor for hearing loss; however, no information is available on auditory preclinical indicators in young chronic cigarette smokers. Cigarette smoking involves exposure to many harmful chemicals including carbon monoxide (CO). In this study, the CO level in 16 young normal hearing male chronic smokers was measured with a CO monitor, and was used as the outcome measure. Subjects were administered a battery of audiological tests that included behavioral and electrophysiologic measures. The goal was to investigate which auditory test measures can be used as potential predictors of the outcome measure. Using ordinary least squares estimation procedures with best-subsets selection and bootstrapped stepwise variable selection procedures, an optimal predictive multiple linear regression model was selected. Results of this approach indicated that auditory brainstem response peak V amplitudes and distortion product otoacoustic emissions had the highest predictive value and accounted for most of the variability.