This Research aims to study Quantitative Structure-Activity Relationship (QSAR) of pyrazoline analogues, designing the new potential compounds as antiamoebic and study the interactions between the new compunds and the drugs target by molecular docking approach. This research was a theoritical research using computational chemistry method. The object of research was 21 novel of 1-N-substituted pyrazoline analogues of thiosemicarbazones with their antiamoebic biological activity. The data of research was obtained from quantum chemistry calculation and statistically analysis using Multiple Linear Regression (MLR). The resulting QSAR equation was Log IC50 = 0.869 + (0.081 x TPSA) + (0.018 x HF) + (0.527 x E-HOMO) + (3.378 x E-LUMO) + (-16.938 x Glob) + (0.234 x LogP), with statistic parameters of n = 21; R2 = 0.933; SEE = 0.14558; FHitung/FTabel = 8.607; PRESS = 0.491. This equation was used as a basic for designing and predicting the new antiamoebic compounds of pyrazoline analogues. The design of new compound of two lead compounds with the Topliss resulted 5 of 18 new compounds having theoretical better activity than the lead compound. Molecular docking study indicated that all of the best compounds have ability to bind to drug target macromolecule.

The purpose of research was to determine the problem solving skill of basic chemical laws at tenth-grade senior high school of  through the application of guided inquiry learning models. The ability is known through a three tier multiple choice diagnostic test. This research was an experimental quasi with pretest-posttest control group design. The  sample consisted of 107 students consisting of 56 experimental class  and 51 control class. Based on the results of the calculation of the F test that F count> F table (10.72> 3.93) with α = 0.05. This means that there was an influence of the application of the guided inquiry learning model to students' ability to solve problems in the basic laws of chemistry. 70.71% of students in the experimental class can understand the problem, plan the solution, carry out the solution, and re-examine the results of the problem solving. Meanwhile, control class students were unable to solve very high problems, namely 24.5% students..

The main need of clean water on Universitas Muhammadiyah Gorontalo (UMGo) especially for bathing, washing and toileting from the groundwater. To utilizing groundwater must to heed water quality. Water quality determined by physical, chemical, and biology parameters. One of this parameters is hardness. Water with very high degrees of hardness is harmful to environment and health. Analysis of hard water degrees from groundwater on Universitas Muhammadiyah Gorontalo area with complexometric titration method has been done. The result shows that degrees of hard water in Yusuf Polapa Mosque, Faculty of agriculture, rectorat, and AMCF building respectively 59,0 mg/L; 74,2 mg/L; 74,0 mg/L dan 57,8 mg/L. This result categorize as soft water. The degrees of hardness in canteen is 81,8 mg/L or moderate water. Therefore, groundwater in Universitas Muhammadiyah Gorontalo area is safe for daily and industry need. Kebutuhan air bersih di lingkungan Universitas Muhammadiyah Gorontalo (UMGo) khususnya mandi, cuci dan kakus (MCK) bersumber dari air tanah. Dalam pemanfaatan air tanah perlu diperhatikan parameter kualitas air. Kualitas air yang baik ditentukan oleh parameter fisika, kimia, dan biologi. Salah satu parameter tersebut adalah tingkat kesadahan. Air tanah yang mengandung tingkat kesadahan yang tinggi dapat berdampak buruk bagi lingkungan dan kesehatan. Telah dilakukan analisis tingkat kesadahan air tanah pada 5 (lima) titik di lingkungan Universitas Muhammadiyah Gorontalo dengan metode titrasi kompleksometri. Berdasarkan hasil analisa, tingkat kesadahan air tanah di Masjid Yusuf Polapa, gedung Fakultas pertanian, gedung rektorat dan gedung AMCF masing-masing adalah 59,0 mg/L; 74,2 mg/L; 74,0 mg/L dan 57,8 mg/L, masuk dalam kategori dengan tingkat kesadahan rendah. Tingkat kesadahan air tanah di sekitar kantin dalam kategori sedang yaitu sebesar 81,8 mg/L. Dengan demikian, air tanah di lingkungan kampus Universitas Muhammadiyah Gorontalo aman digunakan untuk keperluan sehari-hari dan keperluan industri.

Quantitatif Structure-Activity Relationship (QSAR) study of 22 antimalarial compounds of Quinolon-4(1H)-imines derivatives has been done using multilinear regression (MLR) and artificial neural network (ANN) methods. The best QSAR model was obtained from ANN analysis indicated by its higher correlation coefficient (r2) compared to MLR method, i.e. 0.931 with most influential descriptors is qC1, qC5, qC11, qN14 and log P.Keywords: Quinolon-4(1H)-imines, Antimalarial, QSAR, MLR-ANNTelah dilakukan kajian analisis Hubungan Kuantitatif Struktur Aktivitas (HKSA) terhadap 22 senyawa antimalaria turunan Quinolon-4(1H)-imines menggunakan metode regresi multilinear (MLR) dan artificial neural network (ANN). Model HKSA terbaik diperoleh dari hasil analisis menggunakan metode ANN yang ditunjukkan oleh nilai koefisien korelasi (r2) paling tinggi dibandingkan dengan metode MLR yaitu sebesar 0,931 dengan deskriptor paling berpengaruh terhadap aktivitas antimalaria turunan Quinolon-4(1H)-imines, yaitu qC1, qC5, qC11, qN14 dan log P.Kata Kunci: Quinolon-4(1H)-imines, Antimalaria, HKSA, MLR-ANN

Chemistry learning has so far emphasized macroscopic and symbolic aspects as a result of misconceptions and students' low understanding of chemistry. This study aims to determine the influence of science process skill through guided inquiry model on student learning outcomes on acidic-basicsolution topic. The type of research is experimental research with Posttest-Only Control Design. Sampling was done by using Purposive Sampling technique. The sample of research for the experimental class and control class were 31 students, respectively. Data collection using objective test as an instrument that contains test about acidic acid material. Data analysis technique used to test the research hypothesis is t-test. Based on the statistical results obtained the average value of post-test experimental class is 58.55 while for the control class the average post-test value is 39.68. Result of data analysis for learning result show that in significant level 0,05 obtained tcount> t table  (6,22> 1,671),  then H0 rejected or accepted H1. Thus it can be concluded that there is the influence of process skills of science through guided inquiry model on student learning outcomes on acidic acid solution materials.The positive effects are also discussed in this study.