Aim: Brain is one of the commonest sites for metastases in cancer patients and incidence of brain metastases in increasing by the day due to improved survival of cancer patients. Eloquent area Brain metastases may present significant treatment challenges. Very few reports deal with management of eloquent area metastases arising from unusual sources. We present a short series of patients harboring metastatic lesions in eloquent brain region from unusual primary sources.Methods: During a 2-year period from 2013 to 2015, 10 consecutive patients harboring a cerebral metastasis within the eloquent area of brain from an unusual primary source underwent stereotaxy assisted microsurgical resection. No cortical mapping was used for any of the patients. Eloquent locations included the primary sensorimotor and speech cortices. Unusual source was defined as primary cancer not commonly known to metastasize to brain (all sources except lung, breast, melanoma). All patients were discussed at a multi-disciplinary tumor board. We present the clinical results after operative treatment of metastases within the eloquent brain area, with functional outcome at 3 months.Results: There were 5 men and 5 women (mean age 47.6 years) who underwent 10 microsurgical operations after stereotactical localization to remove metastatic lesions in eloquent region of brain. There were no perioperative complications. At 3 months follow up, all patients were alive. There was symptomatic improvement or stabilization after neurological improvement in all of the patients. Karnofsky scores improved in all of the patients at 3 months evaluation. Conclusion:Lot of unusual primary cancers do metastasize to eloquent areas of brain. Complete microsurgical resection of eloquent area metastases from unusual primaries is feasible and beneficial. Patient selection and consequent surgical treatment can lead to significant improvement in the quality of life of such patients.