Coronavirus Disease 2019 (COVID-19) merupakan penyakit infeksi menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) dan ditetapkan sebagai pandemi pada Maret 2020. Manifestasi klinis COVID-19 bervariasi, pemeriksaan diagnostik dan tatalaksana juga mengalami perkembangan yang dinamis. Penelitian ini bertujuan memberikan gambaran karakteristik klinis, komorbiditas, terapi, dan luaran dari 48 pasien COVID-19 yang dirawat inap di RS Immanuel (RSI) Bandung. Data penelitian didapat dari rekam medik RSI periode Maret hingga Oktober 2020. Wanita lebih banyak terkena COVID-19 (54,2 %) dan 8,3% pasien berprofesi sebagai tenaga kesehatan. Rentang usia pasien COVID-19 terbanyak pada usia 51 – 60 tahun (29%). Gejala yang didapat adalah batuk (93,7%), demam (87,5%), sesak (43,7%), nyeri menelan (23%), mual (14,6%), pilek (8,3%), diare, dan anosmia masing-masing pada 6,25% pasien. Dari 48 pasien, didapatkan 12 pasien (25%) meninggal, 31 pasien (64,5%) sembuh, 3 pasien (6,25%) dirujuk, dan 2 pasien (4,16%) pulang atas permintaan sendiri. Mortalitas terbanyak ditemukan pada rentang usia 61 – 70 tahun (33,3%). Tercatat dua orang memilih terapi imunoglobulin intravena. Disimpulkan bahwa karakteristik pasien COVID-19 di RSI terbanyak adalah wanita, rentang usia 51 – 60 tahun, dengan gejala batuk, dan komorbid hipertensi. Mortalitas tercatat sebesar 25% dengan hipertensi dan usia lanjut merupakan komorbid terbanyak pada nonpenyintas COVID-19.Kata kunci: pasien COVID-19; karakteristik; Rumah Sakit Immanuel.

Introduction: Severe Acute Respiratory Syndrome (SARS-CoV-2) can develop into post COVID-19 with one of its main attentions being secondary infection. Candidiasis as fungal pneumonia is one of secondary infection in post COVID-19. It is hard to diagnose and has high mortality. We present a case of candidiasis as fungal pneumonia in post COVID-19 patient.Case: A 47-year-old woman came to the emergency room with major complaints of dyspnoea and jaundice since her second day at home after being discharged from having COVID-19. She previously finished her COVID treatment and tested negative 2 times. She had severe sepsis and her sputum culture was positive for non-albicans Candida. She received anti-fungal treatment and her condition was getting better and her chest X-ray showed less infiltrates than before.Discussion: Fungal respiratory infections generate concern in the expanding population of immunosuppressed patients like COVID-19 patient. The mortality from COVID-19 associated candidiasis is high (19-40%) as one of fungal infection. Marked immune dysregulation in COVID-19 makes system immune becomes impaired, it also harms lung epithelium. In this patient, diagnosis and treatment were challenging.Conclusion: Post COVID-19 is a condition that should be given more attention, especially when it develops secondary infection. Candidiasis as fungal pneumonia is hard to diagnose and can quickly become severe sepsis and has high mortality. Health practitioners should recognize it as soon as possible and give the best treatment for the patient.

Vaccine for COVID-19 is held with the hope of being the pandemic solution but it also gets various responses from various groups, so researchers want to compare the knowledge, attitudes, and participation of health workers and civilians towards the COVID-19 vaccine. The research design used a cross-sectional study with a total sample of 101 respondents from health workers using simple random sampling and civilians using incidental sampling by time. The data were taken in March-April 2021 using a questionnaire at Immanuel Hospital Bandung. Data analysis used univariate and multivariate analysis. The results showed that 84% of health workers and 83.1% of civilians had good knowledge; 99% of health workers and 93% of civilians are supportive; 89% of health workers and 78.2% of civilians participate in the COVID-19 vaccine. The relationship between knowledge and attitudes has a close relationship (p <0.05), as well as knowledge and participation (p <0.05) and attitudes towards participation (p <0.05) in both civilians and health workers. Both groups have good knowledge, supportive attitude and are willing to participate in the COVID-19 vaccine—the better the knowledge, the better the attitudes and participation. Likewise, the better the attitudes, the more willing they are to participate in the COVID-19 vaccine. Keywords: vaccine; COVID-19; knowledge; attitude; participation

Background: One of the issues in post COVID-19 is secondary infection and fungal infection is one of the complications that must be detected at early stage to prevent. Early detection to prevent underdiagnosed and undertreatment. Candida glabrata, one of the pathogens in fungal infection is rare and can acts as infectious agent with immunocompromised patients.Case: A 69-year-old man came to hospital with major complaints of cough and shortness of breath for five days. He was diagnosed COVID-19, After completed treatment the nasopharyngeal PCR swab show negative result for COVID-19. After being discharged, he did several chest X-ray examinations with progressively worsening cough. Chest CT-Scan revealed consolidations and cavity. Sputum culture was positive for Candida glabrata and negative for BTA. He received echinocandins as anti-fungal treatment, which inhibits enzymes that is necessary for fungi’s cell wall synthesis, shows clinical and radiological improvement.Discussion: COVID-19 affect immune system which resulting higher risk for secondary infection. The use of broad-spectrum antibiotics, immune-suppression of the host, and use of medical devices are major risk factors for Candida infections. Meanwhile C. Albicans is still the most common cause of fungal pneumonia by Candida, we should consider C. glabrata as one of its pathogens. Conclusion: COVID-19 affects many aspects in our life, even after we treat the main problem, some patients manifest symptoms later. Diagnosing fungal infection especially invasive candidiasis is quite challenging with higher mortality rate. Not only C. glabrata more uncommon than C. albicans, but also it was one of difficult to treat pathogens.

Introduction: Solitary fibrous tumors (SFT) is a rare group of tumor. Even rarer, it is associated with Doege-Potter syndrome (DPS), which manifests as hypoglycemia due to paraneoplastic syndrome. From searching through national reports and articles, this was the first case of DPS in Indonesia. Case: A 60-year-old woman was admitted to the emergency department with dyspnea and unconscious. The patient’s glucose level showed 21mg/dL. A solid mass on the patient’s right lung was shown on the chest X-ray. A previous biopsy concluded that the patient had a solid fibrous tumor with a history of profound hypoglycemia. The patient underwent tumor resection and got a biopsy of the tumor. After resection, the patient showed no sign of hypoglycemia, and the blood glucose level was stable. We concluded that the patient had DPS, a paraneoplastic syndrome associated with the solid fibrous tumor. Conclusion: Performing an adequate examination and giving prompt treatments can increase the patient’s quality of life, even though it is a rare disease and hard to diagnose. The patient’s condition, evaluated from a clinical condition, chest X-ray, and blood glucose, was better than before getting radical resection.