Easily accessible 3,3′-diindolylmethanes
(DIMs) were utilized
to generate a focused library of indolo[2,3-b]quinolines
(2), chromeno[2,3-b]indoles (3), and 3-alkenyl-oxindoles (4) under 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone
(DDQ)-mediated oxidative conditions. DIMs with ortho-NHTosyl (NHTs)
phenyl group afforded indolo[2,3-b]quinolines (2), whereas DIMs with ortho-hydroxy phenyl groups yielded
chromeno[2,3-b]indoles (3) and 3-alkenyl-oxindoles
(4). The mild conditions and excellent yields of the
products make this method a good choice to access a diverse library
of bioactive molecules from a common starting material. Two optimized
compounds 2a and 2n displayed excellent
activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). Compound 2a showed
the minimum inhibitory concentration values in the concentration between
1 and 4 μg/mL, whereas compound 2n revealed the
values of 1–2 μg/mL. Furthermore, both the compounds
were highly bactericidal and capable to kill the MRSA completely within
360 min. Collectively, the results suggested that both compounds 2a and 2n possess enormous potential to be developed
as anti-MRSA agents.
A facile synthesis of 2, 5‐diamino‐p‐benzoquinones (DABQs) is reported under very mild conditions by mere crystallization. Mechanistic studies by density functional theoretical (DFT) calculations revealed an oxidative C(sp2)‐C(sp2) bond cleavage reaction mechanism via a dioxetane intermediate, from enamine oxidation of a mixture of ethyl vanillin and primary amines by triplet molecular oxygen. A second air oxidation event in the sequence of the reaction that results in C(sp2)‐C(sp2) bond formation is also described by DFT studies. The mechanistic insights enabled synthesis of both symmetric and unsymmetric DABQs from primary amines with a broad substrate scope.
A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes. The reaction proceeds at room temperature by a trifluoroacetic acid mediated Diels-Alder pathway. Synthetic applications of the resulting biaryl-2-carbaldehyde have been demonstrated by conversion into an array of diverse molecules with biological and materials chemistry relevance. The present work offers a complementary route to the existing metal mediated cross-coupling methods for the preparation of biaryls.
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation mediated by DDQ that afforded a diverse array of products are described.
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